TY - CHAP
T1 - Cytopathology of the Upper Urinary Tract
AU - VandenBussche, Christopher J.
AU - Hang, Jen Fan
AU - McIntire, Patrick J.
AU - Miki, Yurina
AU - Peyton, Stephen
AU - Vohra, Poonam
AU - Zhang, Mingjuan Lisa
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2022.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Upper tract (renal and ureteral) urothelial carcinomas (UTUC) account for only 5-10% of all urothelial carcinomas. Cytological examination of voided urine (VU) or washings (barbotages) obtained from the upper urinary tract (UUT) is often a component of the diagnostic workup for UTUC. Obtaining tissue biopsies of UUT lesions can be challenging due to the increased difficulty of visualization and access of these lesions during ureteroscopy. Studies have shown that instrumented/selective UUT specimens (catheterized, washings/barbotages, and brushings) are superior to VU for the detection of UTUC, but the presence of instrumentation artifacts can impede cytological evaluation. This chapter summarizes the utility of UUT cytology, the current understanding of UTUC including its molecular biology, and reviews the relevant current literature.
AB - Upper tract (renal and ureteral) urothelial carcinomas (UTUC) account for only 5-10% of all urothelial carcinomas. Cytological examination of voided urine (VU) or washings (barbotages) obtained from the upper urinary tract (UUT) is often a component of the diagnostic workup for UTUC. Obtaining tissue biopsies of UUT lesions can be challenging due to the increased difficulty of visualization and access of these lesions during ureteroscopy. Studies have shown that instrumented/selective UUT specimens (catheterized, washings/barbotages, and brushings) are superior to VU for the detection of UTUC, but the presence of instrumentation artifacts can impede cytological evaluation. This chapter summarizes the utility of UUT cytology, the current understanding of UTUC including its molecular biology, and reviews the relevant current literature.
KW - Instrumentation
KW - Renal pelvis
KW - Upper tract
KW - Ureter
KW - Urothelial carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85128716259&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-88686-8_7
DO - 10.1007/978-3-030-88686-8_7
M3 - Chapter
AN - SCOPUS:85128716259
SN - 9783030886851
SP - 115
EP - 141
BT - The Paris System for Reporting Urinary Cytology
PB - Springer International Publishing
ER -