Cyanine-Based Polymer Dots with Long-Wavelength Excitation and Near-Infrared Fluorescence beyond 900 nm for in Vivo Biological Imaging

Ming Ho Liu, Tzu Chun Chen, Juvinch R. Vicente, Chun Nien Yao, Yu Chi Yang, Chuan Pin Chen, Pin Wen Lin, Yu Chieh Ho, Jixin Chen, Shu Yi Lin, Yang Hsiang Chan, Yang Hsiang Chan, Yang Hsiang Chan

研究成果: Article同行評審

12 引文 斯高帕斯(Scopus)

摘要

Bioimaging in the near-infrared window is of great importance to study the dynamic processes in vivo with deep penetration, high spatiotemporal resolution, and minimal tissue absorption, scattering, and autofluorescence. In spite of the huge progress on the synthesis of small organic fluorophores and inorganic nanomaterials with emissions beyond 900 nm, it remains a tough challenge to synthesize semiconducting polymers with fluorescence over this region. Here, we synthesized a series of heptamethine cyanine-based polymers with both absorption and emission in the near-infrared region. We prepared these polymers as semiconducting polymer dots (Pdots) in pure water with great biocompatibility. The fluorescence quantum yield of the Pdots can be as high as 14% with a full width at half-maximum of 53 nm, and their single-particle brightness is more than 20 times higher than commercial quantum dots or ∼300 times brighter than Food and Drug Administration (FDA)-approved indocyanine green (ICG) dyes. We further demonstrated the use of cyanine-based Pdots for specific cellular labeling and long-term tumor targeting in mice. We anticipate that these cyanine-based ultrabright Pdots could open up an avenue for next generations of near-infrared fluorescent agents.

原文English
頁(從 - 到)3846-3858
頁數13
期刊ACS Applied Bio Materials
3
發行號6
DOIs
出版狀態Published - 15 6月 2020

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