Current trends and promising clinical utility of IPSC-derived MSC (iMSC)

Shih Hwa Chiou, Han Kiat Alan Ong, Shih Jie Chou, A. F. Aldoghachi, Jit Kai Loh, Nalini Devi Verusingam, Yi Ping Yang*, Yueh Chien

*此作品的通信作者

研究成果: Chapter同行評審

摘要

Mesenchymal stem cells (MSCs) differentiated from human induced pluripotent stem cells (iPSC) or induced MSC (iMSCs) are expected to address issues of scalability and safety as well as the difficulty in producing homogenous clinical grade MSCs as demonstrated by the promising outcomes from preclinical and clinical trials, currently ongoing. The assessment of iMSCs based in vitro and in vivo studies have thus far showed more superior performance as compared to that of the primary or native human MSCs, in terms of cell proliferation, expansion capacity, immunomodulation properties as well as the influence of paracrine signaling and exosomal influence in cell-cell interaction. In this chapter, an overview of current well-established methods in generating a sustainable source of iMSCs involving well defined culture media is discussed followed by the properties of iMSC as compared to that of MSC and its promising prospects for continuous development into potential clinical grade applications.

原文English
主出版物標題Progress in Molecular Biology and Translational Science
編輯Akon Higuchi, Yinghong Zhou, Shih-Hwa Chiou
發行者Elsevier B.V.
頁面131-154
頁數24
ISBN(列印)9780443134111
DOIs
出版狀態Published - 1月 2023

出版系列

名字Progress in Molecular Biology and Translational Science
199
ISSN(列印)1877-1173
ISSN(電子)1878-0814

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