Cucumarioside A 2 -2 causes macrophage activation in mouse spleen

Evgeny A. Pislyagin*, Igor V. Manzhulo, Tatiana Y. Gorpenchenko, Pavel S. Dmitrenok, Sergey A. Avilov, Alexandra S. Silchenko, Yun-Ming Wang, Dmitry L. Aminin

*此作品的通信作者

研究成果: Article同行評審

17 引文 斯高帕斯(Scopus)

摘要

The immunomodulatory effect of triterpene glycoside cucumarioside A2-2 (CA2-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage activating markers iba-1, IL-1β, iNOs, ROS and NO formation, with additional change of macrophage phenotype to M1. The mass spectrometry profiles of peptide/protein were obtained using MALDI-TOF-MS on the different parts of spleen sections isolated by laser mircodissection techniques. It was found that i.p. stimulation of animals with CA2-2 leads to marked changes in the intensity of the characteristic peaks of spleen peptides/proteins, primarily in red pulp.

原文English
文章編號341
頁數15
期刊Marine Drugs
15
發行號11
DOIs
出版狀態Published - 11月 2017

指紋

深入研究「Cucumarioside A 2 -2 causes macrophage activation in mouse spleen」主題。共同形成了獨特的指紋。

引用此