TY - JOUR
T1 - Cortico-cortical phase synchrony in auditory mismatch processing
AU - Hsiao, Fu Jung
AU - Cheng, Chia Hsiung
AU - Liao, Kwong Kum
AU - Lin, Yung Yang
PY - 2010/5
Y1 - 2010/5
N2 - Previous studies have shown a reduced MMN in patients with lesions in the temporal or frontal lobes, suggesting a temporal-frontal involvement in change detection. However, how the temporal lobe interacts with other brain areas in responding to unexpected deviant stimuli remains unclear. This study aimed to evaluate the functional connectivity between cerebral regions by measuring the phase synchrony of magnetoencephalographic (MEG) signals elicited by regular simple tones and their duration-deviants in an oddball paradigm. We measured MEG responses to deviant (1000-Hz frequency, 50-ms duration, probability of 15%) and standard (1000-Hz frequency, 100-ms duration) sounds in 10 healthy adults. By using the Morlet wavelet-based analysis, relative phase synchronization values of 4-40. Hz MEG responses at 150-300. ms after stimulus onset were calculated with respect to a reference channel from the temporal region. Phase synchronization was clearly identified between the temporal and ipsilateral frontal region in the auditory evoked responses. This temporal-frontal synchronization was significantly larger in deviants-elicited than standards-elicited activation at 4-25. Hz in the left hemisphere (p<0.05), and at 4-8. Hz in the right hemisphere (p<0.01). Also, temporal-temporal and temporal-parietal phase synchronies were found in deviants-evoked 4-8. Hz responses.The present results suggest an involvement of temporal-temporal, temporal-frontal, and temporal-parietal neuronal network in detecting auditory change. Phase synchronization analysis may provide a useful window to further understanding of the cerebral reactivity during the processing of auditory deviants.
AB - Previous studies have shown a reduced MMN in patients with lesions in the temporal or frontal lobes, suggesting a temporal-frontal involvement in change detection. However, how the temporal lobe interacts with other brain areas in responding to unexpected deviant stimuli remains unclear. This study aimed to evaluate the functional connectivity between cerebral regions by measuring the phase synchrony of magnetoencephalographic (MEG) signals elicited by regular simple tones and their duration-deviants in an oddball paradigm. We measured MEG responses to deviant (1000-Hz frequency, 50-ms duration, probability of 15%) and standard (1000-Hz frequency, 100-ms duration) sounds in 10 healthy adults. By using the Morlet wavelet-based analysis, relative phase synchronization values of 4-40. Hz MEG responses at 150-300. ms after stimulus onset were calculated with respect to a reference channel from the temporal region. Phase synchronization was clearly identified between the temporal and ipsilateral frontal region in the auditory evoked responses. This temporal-frontal synchronization was significantly larger in deviants-elicited than standards-elicited activation at 4-25. Hz in the left hemisphere (p<0.05), and at 4-8. Hz in the right hemisphere (p<0.01). Also, temporal-temporal and temporal-parietal phase synchronies were found in deviants-evoked 4-8. Hz responses.The present results suggest an involvement of temporal-temporal, temporal-frontal, and temporal-parietal neuronal network in detecting auditory change. Phase synchronization analysis may provide a useful window to further understanding of the cerebral reactivity during the processing of auditory deviants.
KW - Auditory change detection
KW - Cortico-cortical phase synchronization
KW - Humans
KW - Magnetic mismatch negativity (MMNm)
KW - Magnetoencephalography (MEG)
KW - Temporal-frontal network
UR - http://www.scopus.com/inward/record.url?scp=77952964409&partnerID=8YFLogxK
U2 - 10.1016/j.biopsycho.2010.03.019
DO - 10.1016/j.biopsycho.2010.03.019
M3 - Article
C2 - 20380866
AN - SCOPUS:77952964409
SN - 0301-0511
VL - 84
SP - 336
EP - 345
JO - Biological Psychology
JF - Biological Psychology
IS - 2
ER -