Correlation of copper interaction, copper-driven aggregation, and copper-driven H2O2 formation with Aβ40 conformation

Ta Hsien Lin*, Chia Anne Yang, Yung Han Chen, Shyue Chu Ke, Yi Ru Chen, Hsien Bin Huang, Yi Cheng Chen

*此作品的通信作者

研究成果: Article同行評審

9 引文 斯高帕斯(Scopus)

摘要

The neurotoxicity of Aβ is associated with the formation of free radical by interacting with redox active metals such as Cu2+. However, the relationship between ion-interaction, ion-driven free radical formation, and Aβ conformation remains to be further elucidated. In the present study, we investigated the correlation of Cu2+ interaction and Cu2+-driven free radical formation with Aβ40 conformation. The Cu2+-binding affinity for Aβ40 in random coiled form is 3-fold higher than that in stable helical form. Unexpectedly but interestingly, we demonstrate in the first time that the stable helical form of Aβ40 can induce the formation of H2O2 by interacting with Cu2+. On the other hand, the H2O2 generation is repressed at Aβ/Cu2+ molar ratio ≥1 when Aβ40 adopts random coiled structure. Taken together, our result demonstrates that A40 adopted a helical structure that may play a key factor for the formation of free radical with Cu2+ ions.

原文English
文章編號607861
期刊International Journal of Alzheimer's Disease
DOIs
出版狀態Published - 2011

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