Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons

Heather K. Decot, Vijay M.K. Namboodiri, Wei Gao, Jenna A. McHenry, Joshua H. Jennings, Sung Ho Lee, Pranish A. Kantak, Yu Chieh Jill Kao, Manasmita Das, Ilana B. Witten, Karl Deisseroth, Yen Yu Ian Shih*, Garret D. Stuber

*此作品的通信作者

研究成果: Article同行評審

53 引文 斯高帕斯(Scopus)

摘要

Several neuropsychiatric conditions, such as addiction and schizophrenia, may arise in part from dysregulated activity of ventral tegmental area dopaminergic (TH VTA) neurons, as well as from more global maladaptation in neurocircuit function. However, whether TH VTA activity affects large-scale brain-wide function remains unknown. Here we selectively activated TH VTA neurons in transgenic rats and measured resulting changes in whole-brain activity using stimulus-evoked functional magnetic resonance imaging. Applying a standard generalized linear model analysis approach, our results indicate that selective optogenetic stimulation of TH VTA neurons enhanced cerebral blood volume signals in striatal target regions in a dopamine receptor-dependent manner. However, brain-wide voxel-based principal component analysis of the same data set revealed that dopaminergic modulation activates several additional anatomically distinct regions throughout the brain, not typically associated with dopamine release events. Furthermore, explicit pairing of TH VTA neuronal activation with a forepaw stimulus of a particular frequency expanded the sensory representation of that stimulus, not exclusively within the somatosensory cortices, but brain-wide. These data suggest that modulation of TH VTA neurons can impact brain dynamics across many distributed anatomically distinct regions, even those that receive little to no direct TH VTA input.

原文English
頁(從 - 到)615-627
頁數13
期刊Neuropsychopharmacology
42
發行號3
DOIs
出版狀態Published - 1 2月 2017

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