Cooling stimulation on cerebral cortex for epilepsy suppression with integration of micro-invasive electrodes and TE coolers

Jin-Chern Chiou, Lei Chun Chou, Shang Wei Tsai*, Kuan Chou Hou, Chih Wei Chang

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

Epilepsy suppression with cooling stimulation is the primary purpose for this study. In this dissertation, cooling stimulation was implemented and demonstrated on cerebral cortex of rats. Electrodes with needle structure was designed and fabricated by using MEMS technology to minimize the size of device. A TE cooler was used to create cooling source and it can be control via electrical current. A cooler component was integrated with an electrode and a TE cooler, in addition, a thermal sensor was also combined with it to detect temperature variation, which was affected by cooling cerebral cortex. The cooler components were implanted on surface of cerebral with deep brain stimulation and the thermal sensors were penetrated into cortex to measure temperature variation which can verify the functions of cooler components. In our experimental results, electrodes with needle structure can improve efficiency of epilepsy suppression due to the particular structure. Duration, frequency and average single time of epileptic waveforms were used to identify to performance of suppression.

原文English
主出版物標題8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
頁面1249-1252
頁數4
DOIs
出版狀態Published - 2 九月 2013
事件8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013 - Suzhou, China
持續時間: 7 四月 201310 四月 2013

出版系列

名字8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013

Conference

Conference8th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2013
國家/地區China
城市Suzhou
期間7/04/1310/04/13

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