Controllable graphene oxide-based biocompatible hybrid interface as an anti-fibrotic coating for metallic implants

Chong You Chen, Pei Hsuan Tsai, Ya Hui Lin, Chien Yu Huang, Johnson H.Y. Chung, Guan Yu Chen*

*此作品的通信作者

研究成果: Article同行評審

摘要

In tissue engineering, foreign body reactions (FBRs) that may occur after the insertion of medical implants are a considerable challenge. Materials currently used in implants are mainly metals that are non-organic, and the lack of biocompatibility and absence of immune regulations may lead to fibrosis after long periods of implantation. Here, we introduce a highly biocompatible hybrid interface of graphene oxide (GO) and collagen type I (COL-I), where the topological nanostructure can effectively inhibit the differentiation of fibroblasts into myofibroblasts. The structure and roughness of this coating interface can be easily adjusted at the nanoscale level through changes in the GO concentration, thereby effectively inducing the polarization of macrophages to the M1 state without producing excessive amounts of pro-inflammatory factors. Compared to nanomaterials or the extracellular matrix as an anti-fibrotic interface, this hybrid bio-interface has superior mechanical strength, physical structures, and high inflammation. Evidenced by inorganic materials such as glass, titanium, and nitinol, GO-COL shows great potential for use in medical implants and cell-material interfaces.

原文English
文章編號100326
期刊Materials Today Bio
15
DOIs
出版狀態Published - 6月 2022

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