Congenital cleft lip and palate and elevated risks of major psychiatric disorders: A nationwide longitudinal study

Hsiang Hsuan Huang, Ju Wei Hsu, Kai Lin Huang, Tung Ping Su, Tzeng Ji Chen, Shih Jen Tsai*, Mu Hong Chen

*此作品的通信作者

研究成果: Article同行評審

摘要

Background: Congenital cleft lip and palate (CCLP) may be associated with major psychiatric disorders, including autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), schizophrenia, bipolar disorder, and major depressive disorder. Methods: From the Taiwan National Health Insurance Research Database, 1,158 children and adolescents with CCLP and 11,580 age/sex-matched controls without CCLP were included in this study between 2001 and 2010; they were followed up until the end of 2011 to identify the aforementioned major psychiatric disorders. Results: After adjustment for age, sex, income, residence, and family history, the Cox regression model revealed a positive relationship of CCLP with subsequent schizophrenia (hazard ratio [HR]: 7.60, 95% confidence interval [CI]: 2.03–28.54), ASD (HR: 6.03, 95% CI: 1.76–20.61), and ADHD (HR: 7.33, 95% CI: 5.01–10.73). Discussion: These findings suggest that clinicians should be attentive to the presence or emergence of mental health conditions in patients with CCLP. Further studies are necessary to investigate the pathogenesis between CCLP and major psychiatric disorders.

原文English
頁(從 - 到)637-647
頁數11
期刊Clinical Child Psychology and Psychiatry
29
發行號2
DOIs
出版狀態Published - 4月 2024

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