Cone beam X-ray luminescence computed tomography reconstruction with a priori anatomical information

Pei An Lo, Meng Lung Lin, Shih Chun Jin, Jyh Cheng Chen, Syue Liang Lin, C. Allen Chang, Huihua Kenny Chiang

研究成果: Conference contribution同行評審

8 引文 斯高帕斯(Scopus)


X-ray luminescence computed tomography (XLCT) is a novel molecular imaging modality that reconstructs the optical distribution of x-ray-excited phosphor particles with prior information of anatomical CT image. The prior information improves the accuracy of image reconstruction. The system can also present anatomical CT image. The optical system based on a highly sensitive charge coupled device (CCD) is perpendicular to a CT system. In the XLCT system, the x-ray was adopted to excite the phosphor of the sample and CCD camera was utilized to acquire luminescence emitted from the sample in 360-degree projections in free-space. In this study, the fluorescence diffuse optical tomography (FDOT)-like algorithm was used for image reconstruction, the structural prior information was incorporated in the reconstruction by adding a penalty term to the minimization function. The phosphor used in this study is Gd2O2S:Tb. For the simulation and experiments, the data was collected from 16 projections. The cylinder phantom was 40 mm in diameter and contains 8 mm diameter inclusion; the phosphor in the in vivo study was 5 mm in diameter at a depth of 3 mm. Both the estimation errors were no more than 5%. Based on the results from these simulation and experimental studies, the novel XLCT method has demonstrated the feasibility for in vivo animal studies.

主出版物標題Reflection, Scattering, and Diffraction from Surfaces IV
編輯Leonard M. Hanssen
出版狀態Published - 2014
事件Reflection, Scattering, and Diffraction from Surfaces IV - San Diego, United States
持續時間: 17 8月 201418 8月 2014


名字Proceedings of SPIE - The International Society for Optical Engineering


ConferenceReflection, Scattering, and Diffraction from Surfaces IV
國家/地區United States
城市San Diego


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