Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis

Xiaohui Yan, Jian Jun Chen, Ajeeth Adhikari, Christiana N. Teijaro, Huiming Ge, Ivana Crnovcic, Chin-Yuan Chang, Thibault Annaval, Dong Yang, Christoph Rader, Ben Shen*

*此作品的通信作者

研究成果: Article同行評審

22 引文 斯高帕斯(Scopus)

摘要

Comparative analyses of the four known anthraquinone-fused enediynes biosynthetic gene clusters identified four genes, tnmE6, tnmH, tnmL, and tnmQ, unique to the tnm gene cluster. Larger scale fermentation of both the S. sp. CB03234 wild-type and the δtnmH and δtnmL mutant strains resulted in the characterization of 20 new tiancimycin (TNM) congeners, including five enediynes. These findings enabled a proposal for the late stage of TNM biosynthesis featuring an intermediate possibly common for all anthraquinone-fused enediynes.

原文English
頁(從 - 到)5918-5921
頁數4
期刊Organic Letters
20
發行號18
DOIs
出版狀態Published - 21 9月 2018

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