Background: Choking is common among psychiatric patients and represents one of the main causes of death in this patient population. Purpose: We aimed to identify common factors associated with choking among psychiatric patients. Methods: The demographic information andmedical history of 250 psychiatric patients living in an acute psychiatricward were retrieved from medical charts, interview records, and check lists. Coughing while eating and swallowing difficulties were assessed based on patient self-reports. The main outcomes were choking while taking drugs (CTD) as observed by nursing staffs and choking experiences during hospitalization (CEH) as reported by the patients. Chi-square tests were used to examine the potential associations among the independent variables.Multiple logistic regression was used to further examine those independent variables found to be significantly associated with CTD to estimate their relative contributions. Results: CEHwas reported in 50.8%, and CTDwas observed in 17.6% of study participants. Use of anxiolytics, consuming a semiliquid or liquid diet, coughing while eating, and swallowing difficultieswere found to be associatedwith CTD. Coughingwhile eating was the only independent variable associated with CEH. Further logistic regression on the relationships between CTD and variables including the use of anxiolytics, coughingwhile eating, and swallowing difficulties showed the independent contributions of these variables in the model. The odds ratios were 12.8 (p = .003), 16.7 (p G .001), and 21.7 (p = .001) for each of the three respective variables. Conclusion: The use of anxiolytics, coughing while eating, and swallowing difficulties all potentially contributed to the choking events in our sample. Additional precautions should thus be taken in caring for psychiatric patients who use anxiolytics, who have a history of coughing while eating, or who exhibit swallowing difficulties to prevent choking events.