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Combinatorial computational approaches to identify tetracycline derivatives as flavivirus inhibitors
Jinn-Moon Yang
, Yan Fu Chen
, Yu Yin Tu
, Kuei Rong Yen
, Yun-Liang Yang
*
*
此作品的通信作者
生物科技學系
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引文 斯高帕斯(Scopus)
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Keyphrases
Biological Validation
25%
Cellular Toxicity
25%
Clinical Compounds
25%
Compound Toxicity
25%
Computational Approach
100%
Confirmatory Assay
25%
Conformational Rearrangement
100%
Dengue Virus
50%
Dengue Virus Envelope
50%
Design Basis
25%
Doxycycline
25%
Drug Target
50%
Envelope Protein
50%
Flavivirus Inhibitors
100%
Host Cell
50%
Hydrophobic Interaction
25%
Inhibitory Effect
25%
Mammalian Host
25%
Membrane Fusion
50%
Molecular Docking
25%
New Leads
25%
Plaque Formation
50%
Rolitetracycline
25%
Structural Database
25%
Structural Information
50%
Tetracyclic
25%
Tetracycline Derivatives
100%
Viral Entry
100%
Virtual Screening
25%
Virus Propagation
50%
Immunology and Microbiology
Conformation
25%
Dengue Virus
100%
Flavivirus
100%
Host Cell
50%
Membrane Fusion
50%
Molecular Docking
25%
Structural Characteristics
25%
Viral Entry
100%
Viral Envelope
50%
Pharmacology, Toxicology and Pharmaceutical Science
Compounds of Lead
25%
Dengue Virus
100%
Doxycycline
25%
Flavivirus
100%
Lead Compound
25%
Rolitetracycline
25%
Tetracycline
100%
Virtual Screening
25%
Virus Envelope Protein
50%