Colorectal carcinoma: From tumorigenesis to treatment

W. S. Wang, P. M. Chen, Y. Su*

*此作品的通信作者

研究成果: Review article同行評審

37 引文 斯高帕斯(Scopus)

摘要

Colorectal carcinoma (CRC) is a complicated and often fatal genetic disease. Fortunately, owing to rapid expansion of knowledge and technology development in oncology, much progress has been made regarding the diagnosis, understanding of the molecular genetics and malignant progression, as well as the novel regimens of CRC. In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog signaling, the intriguing involvement of thymosin β-4, and the possible contribution of the putative colon (cancer) stem cells in CRC tumorigenesis. Current treatments as well as several potentially applicable therapeutic strategies for CRC are also discussed.

原文English
頁(從 - 到)663-671
頁數9
期刊Cellular and Molecular Life Sciences
63
發行號6
DOIs
出版狀態Published - 3月 2006

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