@article{44b237925bfa4dc198203fe91d9d89f9,
title = "Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis",
abstract = "Antiangiogenesis is an efficient therapy for eliminating colon cancers, but because of recurrence it remains only palliative. We hypothesized that certain populations of tumor cells resist antiangiogenesis-induced apoptosis and explored the underlying mechanism. We demonstrated that the CD133+ population of cells in colon cancer is resistant to anti-angiogenesis therapy. Additionally, we identified an anti-apoptotic signaling pathway responsible for this resistance involving PP2A, p38MAPK, MAPKAPK2, and Hsp27. Thus, this pathway may offer a new avenue to develop target therapy for colorectal cancer.",
keywords = "Avastin, Cancer stem cells, Colon cancer, Hypoxia, Serum-free",
author = "Lin, {Shih Pei} and Lee, {Yi Ting} and Yang, {Shung Haur} and Miller, {Stephanie A.} and Chiou, {Shih Hwa} and Hung, {Mien Chie} and Hung, {Shih Chieh}",
note = "Funding Information: This study was supported in part by the National Science Council (97-3111-B-010-001, and 99-3111-B-010-005-), Taipei Veterans General Hospital (V98E1-002), the MD Anderson Cancer Center/China Medical University and Hospital Sister Institution Fund, and the National Yang-Ming University, Ministry of Education. ",
year = "2013",
month = jan,
day = "28",
doi = "10.1016/j.canlet.2012.08.036",
language = "English",
volume = "328",
pages = "226--234",
journal = "Cancer Letters",
issn = "0304-3835",
publisher = "Elsevier Ireland Ltd",
number = "2",
}
