@inproceedings{1b7118b53a344d82a793c4fc1d553586,
title = "Coherent interaction of optical second harmonic generation in collagen fibrils",
abstract = "We present the first experimental comparison between optical second harmonic generation images and atomic force microscope images in a matrix of nano-scaled collagen fibrils. Substantial variation of forward and backward propagated second harmonic generation radiation is observed in a single collagen fibril and is nicely correlated with the accurately determined thickness from an atomic force microscope. Contradicting to conventional nonlinear optical theory, our result indicates a linear relationship between fibril thickness and forward / backward second harmonic generation ratio. This is the first demonstration of estimating fibril thickness with nanometer precision by a noninvasive optical method.",
keywords = "Atomic force microscope, Nonlinear scattering, Optical interference, Radiation pattern, Three-dimensional microscopy, Type I collagen",
author = "Chu, {Shi Wei} and Tai, {Shih Peng} and Chan, {Ming Che} and Sun, {Chi Kuang} and Hsiao, {I. Ching} and Lin, {Chi Hung} and Chen, {Yung Chih} and Lin, {Bai Ling}",
year = "2008",
doi = "10.1117/12.761033",
language = "English",
isbn = "9780819470355",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
booktitle = "Multiphoton Microscopy in the Biomedical Sciences VIII",
note = "Multiphoton Microscopy in the Biomedical Sciences VIII ; Conference date: 20-01-2008 Through 22-01-2008",
}