CloudTSS: A TagSNP selection approach on cloud computing

Che Lun Hung*, Yaw Ling Lin, Guan Jie Hua, Yu Chen Hu

*此作品的通信作者

研究成果: Conference contribution同行評審

5 引文 斯高帕斯(Scopus)

摘要

SNPs are fundamental roles for various applications including medical diagnostic, phylogenies and drug design. They provide the highest-resolution genetic fingerprint for identifying disease associations and human features. Genetic variants that are near each other tend to be inherited together; these regions of linked variants are known as haplotypes. Recently, genetics researches revealed that SNPs within certain haplotype blocks induce only a few distinct common haplotypes in the majority of the population. The existence of haplotype block structure has serious implications for association-based methods for the mapping of disease genes. This paper proposes a parallel haplotype block partition and SNPs selection method under a diversity function by using the Hadoop MapReduce framework. The experiment shows that the proposed MapReduce-paralleled combinatorial algorithm performs well on the real-world data obtained in from the HapMap data set; the computation efficiency can be significantly improved proportional to the number of processors being used.

原文English
主出版物標題Grid and Distributed Computing - International Conference, GDC 2011, Held as Part of the Future Generation Information Technology Conference, FGIT 2011, Proceedings
頁面525-534
頁數10
DOIs
出版狀態Published - 2011
事件International Conference on Grid and Distributed Computing, GDC 2011, Held as Part of the 3rd International Mega-Conference on Future-Generation Information Technology, FGIT 2011 - Jeju Island, Korea, Republic of
持續時間: 8 12月 201110 12月 2011

出版系列

名字Communications in Computer and Information Science
261 CCIS
ISSN(列印)1865-0929

Conference

ConferenceInternational Conference on Grid and Distributed Computing, GDC 2011, Held as Part of the 3rd International Mega-Conference on Future-Generation Information Technology, FGIT 2011
國家/地區Korea, Republic of
城市Jeju Island
期間8/12/1110/12/11

指紋

深入研究「CloudTSS: A TagSNP selection approach on cloud computing」主題。共同形成了獨特的指紋。

引用此