Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer

Chun Ying Wu, Ming Shiang Wu, Yi Ju Chen, Chien Jen Chen, Hsiao Ping Chen, Chia Tung Shun, Gran Hum Chen, Shih Pei Huang, Jaw Town Lin*

*此作品的通信作者

研究成果: Article同行評審

56 引文 斯高帕斯(Scopus)

摘要

Aims: Single nucleotide polymorphisms in matrix metalloproteinase-2 (MMP-2) -1306 C/T and tissue inhibitor of metalloproteinase-2 (TIMP-2) -418 G/C abolish the Sp-1 binding site and down-regulate expression of these genes. We aim to elucidate the role of MMP-2 and TIMP-2 in clinicopathological manifestations of gastric cancer. Methods: We enrolled 240 gastric cancer patients and 283 controls. DNA was extracted from peripheral blood leucocytes. MMP-2 and TIMP-2 genotypes were analysed by PCR-direct sequencing and PCR-RFLP method, respectively. Results: MMP-2 and TIMP-2 genotypes were not associated with gastric cancer development. However, patients with MMP-2 -1306 C/C genotype showed higher risk of lymphatic invasion (odds ratio (OR) = 2.77, p = 0.01) and venous invasion (OR = 2.93, p = 0.012). TIMP-2 G/G genotype was associated with serosal invasion (OR = 1.89, p = 0.009), lymph node metastasis (OR = 2.19, p = 0.021), lymphatic invasion (OR = 2.87, p = 0.016) and venous invasion (OR = 2.65, p = 0.033). Conclusion: Our results suggest MMP-2 and TIMP-2 genotypes play a crucial role in gastric cancer invasion, but not with development of gastric cancer.

原文English
頁(從 - 到)799-808
頁數10
期刊European Journal of Cancer
43
發行號4
DOIs
出版狀態Published - 3月 2007

指紋

深入研究「Clinicopathological significance of MMP-2 and TIMP-2 genotypes in gastric cancer」主題。共同形成了獨特的指紋。

引用此