摘要
Aims: Single nucleotide polymorphisms in matrix metalloproteinase-2 (MMP-2) -1306 C/T and tissue inhibitor of metalloproteinase-2 (TIMP-2) -418 G/C abolish the Sp-1 binding site and down-regulate expression of these genes. We aim to elucidate the role of MMP-2 and TIMP-2 in clinicopathological manifestations of gastric cancer. Methods: We enrolled 240 gastric cancer patients and 283 controls. DNA was extracted from peripheral blood leucocytes. MMP-2 and TIMP-2 genotypes were analysed by PCR-direct sequencing and PCR-RFLP method, respectively. Results: MMP-2 and TIMP-2 genotypes were not associated with gastric cancer development. However, patients with MMP-2 -1306 C/C genotype showed higher risk of lymphatic invasion (odds ratio (OR) = 2.77, p = 0.01) and venous invasion (OR = 2.93, p = 0.012). TIMP-2 G/G genotype was associated with serosal invasion (OR = 1.89, p = 0.009), lymph node metastasis (OR = 2.19, p = 0.021), lymphatic invasion (OR = 2.87, p = 0.016) and venous invasion (OR = 2.65, p = 0.033). Conclusion: Our results suggest MMP-2 and TIMP-2 genotypes play a crucial role in gastric cancer invasion, but not with development of gastric cancer.
原文 | English |
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頁(從 - 到) | 799-808 |
頁數 | 10 |
期刊 | European Journal of Cancer |
卷 | 43 |
發行號 | 4 |
DOIs | |
出版狀態 | Published - 3月 2007 |