Clinicopathologic features and prognostic analysis of MSI-high colon cancer

Chun Chi Lin, Yi Ling Lai, Tzu Chen Lin, Wei Shone Chen, Jeng Kai Jiang, Shung Haur Yang, Huann Sheng Wang, Yuan Tzu Lan, Wen Yih Liang, Hui Mei Hsu, Jen Kou Lin, Shih Ching Chang*

*此作品的通信作者

研究成果: Article同行評審

34 引文 斯高帕斯(Scopus)

摘要

Purpose The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. Methods Microsatellite status was identified by genotyping. The clinicopathologic differences between two groups (MSI-H vs. MSI-L/S) and the prognostic value of MSI were analyzed. Results From 1993 to 2006, 709 sporadic colon cancer patients were enrolled. MSI-H colon cancers showed significant association with poorly differentiated (28.3% vs. 7.2%, p=0.001), proximally located (76.7% vs. 34.5%, p=0.001), more high mucin-containing tumor (10.0% vs. 5.1%, p=0.001) and female predominance (56.7% vs. 30.2%, p=0.001). In multivariate analysis, MSI-H is an independent factor for better overall survival (HR, 0.459; 95% CI, 0.241-0.872, p=0.017). Conclusions Based on the hospital-based study, MSI-H colon cancers demonstrated distinguished clinicopathologic features from MSI-L/S colon cancers. MSI-H is an independent favorable prognostic factor for overall survival in colon cancer.

原文English
頁(從 - 到)277-286
頁數10
期刊International Journal of Colorectal Disease
27
發行號3
DOIs
出版狀態Published - 3月 2012

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