Clinical manifestation and disease progression in COVID-19 infection

Ping Hsing Tsai, Wei Yi Lai, Yi Ying Lin, Yung Hung Luo, Yi Tsung Lin, Hsiao Kang Chen, Yuh Min Chen, Yi Chun Lai, Li Chiao Kuo, Shew Dan Chen, Kao Jung Chang, Cheng Hsuan Liu, Shih Chieh Chang*, Fu Der Wang, Yi Ping Yang


研究成果: Review article同行評審

12 引文 斯高帕斯(Scopus)


Coronavirus disease 2019 (COVID-19) is mainly an infectious disease of the respiratory system transmitted through air droplets, and pulmonary symptoms constitute main presentations of this disease. However, COVID-19 demonstrates a clinically diverse manifestation ranging from asymptomatic presentation to critically illness with severe pneumonia, acute respiratory distress syndrome, respiratory failure, or multiple organ failure. Accumulating evidences demonstrated that COVID-19 has extrapulmonary involvement, including neurological, smelling sensation, cardiovascular, digestive, hepatobiliary, renal, endocrinologic, dermatologic system, and others. Over a third of COVID-19 patients manifest a wide range of neurological symptoms involving the central/peripheral nervous system. Underlying cardiovascular comorbidities were associated with detrimental outcomes, meanwhile the occurrence of cardiovascular complications correlate to poor survival. Gastrointestinal symptoms frequently occur and have been associated with a longer period of illness. Impaired hepatic functions were associated with the severity of the disease. Higher rate of acute kidney injury was reported in critically ill patients with COVID-19. Endocrinologic presentations of COVID-19 include exacerbating hyperglycemia, euglycemic ketosis, and diabetic ketoacidosis. The most common cutaneous manifestation was acro-cutaneous (pernio or chilblain-like) lesions, and other skin lesions consist of maculopapular rash, vesicular lesions, livedoid/necrotic lesions, exanthematous rashes, and petechiae. This review article summarized the general clinical signs and symptoms, radiologic features, and disease manifestation with progression in patients with COVID-19.

頁(從 - 到)3-8
期刊Journal of the Chinese Medical Association
出版狀態Published - 一月 2021


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