CLEC5A is a critical receptor in innate immunity against Listeria infection

Szu Ting Chen, Fei Ju Li, Tzy Yun Hsu, Shu Mei Liang, Yi Chen Yeh, Wen Yu Liao, Teh Ying Chou, Nien Jun Chen, Michael Hsiao, Wen Bin Yang, Shie Liang Hsieh*

*此作品的通信作者

研究成果: Article同行評審

63 引文 斯高帕斯(Scopus)

摘要

The C-type lectin member 5A (CLEC5A) is a pattern recognition receptor for members of the Flavivirus family and has critical functions in response to dengue virus and Japanese encephalitis virus. Here we show that CLEC5A is involved in neutrophil extracellular trap formation and the production of reactive oxygen species and proinflammatory cytokines in response to Listeria monocytogenes. Inoculation of Clec5a -/- mice with L. monocytogenes causes rapid bacterial spreading, increased bacterial loads in the blood and liver, and severe liver necrosis. In these mice, IL-1β, IL-17A, and TNF expression is inhibited, CCL2 is induced, and large numbers of CD11b+Ly6ChiCCR2hiCX3CR1low inflammatory monocytes infiltrate the liver. By day 5 of infection, these mice also have fewer IL-17A+ γδ T cells, severe liver necrosis and a higher chance of fatality. Thus, CLEC5A has a pivotal function in the activation of multiple aspects of innate immunity against bacterial invasion.

原文English
文章編號299
期刊Nature Communications
8
發行號1
DOIs
出版狀態Published - 1 12月 2017

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