Cisd2 is essential to delaying cardiac aging and to maintaining heart functions

Chi Hsiao Yeh*, Zhao Qing Shen, Shao Yu Hsiung, Pei Chun Wu, Yuan Chi Teng, Yi Ju Chou, Su Wen Fang, Chian Feng Chen, Yu Ting Yan, Lung Sen Kao, Cheng Heng Kao, Ting Fen Tsai

*此作品的通信作者

研究成果: Article同行評審

33 引文 斯高帕斯(Scopus)

摘要

CDGSH iron-sulfur domain-containing protein 2 (Cisd2) is pivotal to mitochondrial integrity and intracellular Ca2+ homeostasis. In the heart of Cisd2 knockout mice, Cisd2 deficiency causes intercalated disc defects and leads to degeneration of the mitochondria and sarcomeres, thereby impairing its electromechanical functioning. Furthermore, Cisd2 deficiency disrupts Ca2+ homeostasis via dysregulation of sarco/endoplasmic reticulum Ca2+-ATPase (Serca2a) activity, resulting in an increased level of basal cytosolic Ca2+ and mitochondrial Ca2+ overload in cardiomyocytes. Most strikingly, in Cisd2 transgenic mice, a persistently high level of Cisd2 is sufficient to delay cardiac aging and attenuate age-related structural defects and functional decline. In addition, it results in a younger cardiac transcriptome pattern during old age. Our findings indicate that Cisd2 plays an essential role in cardiac aging and in the heart’s electromechanical functioning. They highlight Cisd2 as a novel drug target when developing therapies to delay cardiac aging and ameliorate age-related cardiac dysfunction.

原文English
文章編號e3000508
期刊PLOS BIOLOGY
17
發行號10
DOIs
出版狀態Published - 2019

指紋

深入研究「Cisd2 is essential to delaying cardiac aging and to maintaining heart functions」主題。共同形成了獨特的指紋。

引用此