Chlorine-containing polyacetoxybriarane diterpenoids from the octocoral Junceella fragilis

Hai Nhat Do, Yu Ta Chen, Su Ying Chien, You Ying Chen, Mingzi M. Zhang, Lun Kelvin Tsou, Jih Jung Chen, Zhi Hong Wen, Yi Hao Lo, Li Guo Zheng*, Ping Jyun Sung*

*此作品的通信作者

研究成果: Article同行評審

摘要

The chemical screening of an octocoral identifed as Junceella fragilis has led to the isolation of five chlorinated briarane-type diterpenoids, including three known metabolites, gemmacolide X (1), frajunolide I (2), and fragilide F (3), along with two new analogs, 12α-acetoxyfragilide F (4) and 12α-acetoxyjunceellin (5). Single-crystal X-ray diffraction analysis was carried out to determine the absolute configurations of 1 and 2, while the structures of new compounds 4 and 5 were ascertained with 2D NMR experiments. Briaranes 1 and 3-5 were active in enhancing alkaline phosphatase (ALP) activity.

原文English
頁(從 - 到)17195-17201
頁數7
期刊RSC Advances
14
發行號24
DOIs
出版狀態Published - 28 5月 2024

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