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Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes
Ning Deng
, Yun Yun Wu
, Yanan Feng
, Wen Chieh Hsieh
, Jen Shin Song
, Yu Shiuan Lin
, Ya Hsien Tseng
, Wan Jhu Liao
, Yi Fan Chu
, Yu Cheng Liu
, En Cheng Chang
, Chia Rung Liu
,
Sheh Yi Sheu
, Ming Tsan Su
, Hung Chih Kuo
, Stanley N. Cohen
*
,
Tzu Hao Cheng
*
*
此作品的通信作者
生命科學系暨基因體科學研究所
腦科學研究中心
國立陽明交通大學
生命科學院
生化暨分子生物研究所
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引文 斯高帕斯(Scopus)
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Keyphrases
Gene Products
100%
Complex Formation
100%
Mutant Huntingtin
100%
Huntingtin
100%
Mutant Phenotype
100%
Chemical Interference
100%
Huntington's Disease
60%
Nucleotide Repeat Expansion
60%
Mutant Alleles
40%
SUPT5H
40%
6-Azauridine
40%
Gene Expression
20%
Small Interfering RNA (siRNA)
20%
Biological Response
20%
Cell Culture
20%
Dose Effect
20%
Culture in Vitro
20%
Photoreceptor Cells
20%
Bioluminescent Assay
20%
Disease-related Proteins
20%
Neurodegenerative Diseases
20%
Gene-gene
20%
Drosophilidae
20%
RNA Polymerase II (RNAPII)
20%
Chemical Compounds
20%
Drosophila Melanogaster
20%
Fluorescence Assay
20%
Affective Expression
20%
Mutated Genes
20%
Mediated Reduction
20%
Phenotypic Effects
20%
Transcription Elongation
20%
Biochemical Effects
20%
Repeat Expansion
20%
Disease Mitigation
20%
Gene mutant
20%
Biochemistry, Genetics and Molecular Biology
Gene Product
100%
Complex Formation
100%
Huntingtin
100%
DSIF
100%
Allele
66%
Nucleotide Repeat
50%
Gene Expression
16%
Small Interfering RNA
16%
Animal Model
16%
RNA Polymerase II
16%
Drosophila Melanogaster
16%
Fluorescence Assay
16%
Messenger RNA
16%
Photoreceptor Cell
16%
Neuroscience
Gene Product
100%
Complex Formation
100%
Huntingtin
100%
Nucleotide Repeat
50%
Huntington's Disease
33%
In Vivo
16%
In Vitro
16%
Gene Expression
16%
Photoreceptor
16%
Neurodegenerative Disorder
16%
Drosophila Melanogaster
16%
RNA Polymerase II
16%
Small Interfering RNA
16%
Messenger RNA
16%