@inproceedings{cbd5204e70454e49af4a9a5276fc2db9,
title = "Characterization of auto-fluorescence urine crystals from gout patients using confocal microscopy and micro-Raman system for urolithiasis prediction",
abstract = "The major etiologies of gout and kidney stone formation are similar hyperuremia, which is caused by unbalanced uric acid production/exertion. And gout is one of the important risk factor that promotes kidney stone formation. It's worth noting that crystals retension/aggregation is the early stage of stone formation. However, the mechanism between gout and crystalluria remains unclear. Our previous studies found good correlation between auto-fluorescent crystals and urolithiasis. Higher proportion of auto-fluorescent crystalluria in gout patients were also noted. It this paper, we demonstrated characterization of auto-fluorescent urinary crystals in gout patients by micro-Raman system and laser confocal microscopy. Our purpose is to figure out the mechanism among gout flare, urolithiasis and auto-fluorescent crystal retention. And the results supported that fluorophore inside the crystals may be a powerful indicator for crystals retention. Further studies are required to validate our hypothesis.",
keywords = "Auto-fluorescence, Gout, Laser confocal scanning microscopy(CLSM), Micro-Raman spectroscopy(MRS), Urine crystals, Urolithiasis",
author = "Chen, {Zih Ting} and Wang, {Chih Hao} and Chiang, {Huihua Kenny}",
note = "Publisher Copyright: {\textcopyright} COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.; Biomedical Spectroscopy, Microscopy, and Imaging 2020 ; Conference date: 06-04-2020 Through 10-04-2020",
year = "2020",
doi = "10.1117/12.2555440",
language = "English",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Jurgen Popp and Csilla Gergely",
booktitle = "Biomedical Spectroscopy, Microscopy, and Imaging",
address = "United States",
}