Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis

Ming Hui Yang, Pei Yu Chu, Sharon Chia Ju Chen, Tze Wen Chung, Wen Cheng Chen, Lia Beng Tan, Wei Chih Kan, Hsien Yi Wang, Shih Bin Su, Yu Chang Tyan*

*此作品的通信作者

研究成果: Article同行評審

27 引文 斯高帕斯(Scopus)

摘要

Human urine contains a large number of proteins and peptides (the urinary proteome). Global analysis of the human urinary proteome is important for understanding urinary tract diseases. Bladder cancer is the most common urological cancer with higher incidence rates in endemic areas of Blackfoot disease (BFD) in southern Taiwan. The aim of this study was to use the proteomic approach to establish urinary protein biomarkers of bladder cancer. ADAM28, identified by proteomic approaches and confirmed by Western blotting, showed significant differences compared with normal individuals, so it may be a biomarker of bladder cancer.

原文English
頁(從 - 到)714-720
頁數7
期刊Biochemical and Biophysical Research Communications
411
發行號4
DOIs
出版狀態Published - 12 8月 2011

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