Characteristics of pre-S2 region of hepatitis B virus

Szecheng J. Lo; Ming Lii Chen; Mei Ling Chien; Yan-Hwa Wu Lee

doi:10.1016/0006-291X(86)90006-9

Characteristics of pre-S2 region of hepatitis B virus

Szecheng J. Lo^*, Ming Lii Chen, Mei Ling Chien, Yan-Hwa Wu Lee

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生物科技學系

研究成果: Article › 同行評審

3 引文斯高帕斯（Scopus）

摘要

The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.

原文	English
頁（從 - 到）	382-388
頁數	7
期刊	Biochemical and Biophysical Research Communications
卷	135
發行號	2
DOIs	https://doi.org/10.1016/0006-291X(86)90006-9
出版狀態	Published - 13 3月 1986

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title = "Characteristics of pre-S2 region of hepatitis B virus",

abstract = "The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.",

author = "Lo, {Szecheng J.} and Chen, {Ming Lii} and Chien, {Mei Ling} and {Wu Lee}, Yan-Hwa",

year = "1986",

month = mar,

day = "13",

doi = "10.1016/0006-291X(86)90006-9",

language = "English",

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journal = "Biochemical and Biophysical Research Communications",

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TY - JOUR

T1 - Characteristics of pre-S2 region of hepatitis B virus

AU - Lo, Szecheng J.

AU - Chen, Ming Lii

AU - Chien, Mei Ling

AU - Wu Lee, Yan-Hwa

PY - 1986/3/13

Y1 - 1986/3/13

N2 - The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.

AB - The nucleotide sequence of our cloned HBV DNA (subtype adw) has been determined. When the 165-nucleotide sequence of the pre-S2 region was compared with 7 other published sequences (subtypes adw, adr, ayw, and adyw), we found 38 nucleotide substitutions among different subtypes and 4 (adr) or 6 (adw and ayw) substitutions within the same subtype. Analysis of the predicted amino acid sequence from the known nucleotide sequences indicates that: 1) there are 20 amino acid substitutions, 2) the longest conserved amino acid sequence is located between amino acids 23 to 34, and 3) the 54th amino acid is identical within the same subtype but varies in different subtypes.

UR - http://www.scopus.com/inward/record.url?scp=0022498288&partnerID=8YFLogxK

U2 - 10.1016/0006-291X(86)90006-9

DO - 10.1016/0006-291X(86)90006-9

M3 - Article

C2 - 3754440

AN - SCOPUS:0022498288

SN - 0006-291X

VL - 135

SP - 382

EP - 388

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Characteristics of pre-S2 region of hepatitis B virus

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