Change of renal gallium uptake correlated with change of inflammation activity in renal pathology in lupus nephritis patients

Tsu Yi Hsieh, Yi Ching Lin, Wei Ting Hung, Yi Ming Chen, Mei Chin Wen, Hsin Hua Chen, Wan Yu Lin, Chia Wei Hsieh, Ching Tsai Lin, Kuo Lung Lai, Kuo Tung Tang, Chih Wei Tseng, Wen Nan Huang, Yi Hsing Chen, Shih Chuan Tsai*, Yi Da Wu

*此作品的通信作者

研究成果: Article同行評審

摘要

Background: Lupus nephritis (LN) often lead to end-stage renal disease in systemic lupus erythematosus patients. This study aimed to investigate the clinical application of renal gallium-67 scans for determining renal histological parameters in LN patients. Methods: Between 2006 and 2018, 237 biopsy-proven and 35 repeat biopsies LN patients who underwent renal gallium scans before or after biopsy were included for analysis. The classification and scoring of LN were assessed according to the International Society of Nephrology/Renal Pathology Society. A delayed 48-h gallium scan was performed and interpreted by semiquantitative methods using left kidney/spine (K/S) ratio. The renal histological results were compared with gallium uptake. Results: Out of 237 participants, 180 (76%) had proliferative LN. Baseline gallium left K/S ratio was significantly higher in class IV LN as compared to class III (median (interquartile range, IQR): 1.16 (1.0–1.3), 0.95 (0.9–1.1), respectively, p <0.001). Furthermore, changes in gallium uptake between two biopsies were positively correlated with changes activity index (r = 0.357, p = 0.035), endocapillary hypercellularity (r = 0.385, p = 0.032), and neutrophils infiltration (r = 0.390, p = 0.030) in renal pathology. Conclusions: Renal gallium uptake is associated with active inflammation in LN. Changes in renal gallium uptake positively correlated with changes in activity index in renal pathology.

原文English
文章編號4654
期刊Journal of Clinical Medicine
10
發行號20
DOIs
出版狀態Published - 1 10月 2021

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