CCL7 as a novel inflammatory mediator in cardiovascular disease, diabetes mellitus, and kidney disease

Ting Ting Chang*, Ching Chen, Jaw Wen Chen

*此作品的通信作者

研究成果: Review article同行評審

19 引文 斯高帕斯(Scopus)

摘要

Chemokines are key components in the pathology of chronic diseases. Chemokine CC motif ligand 7 (CCL7) is believed to be associated with cardiovascular disease, diabetes mellitus, and kidney disease. CCL7 may play a role in inflammatory events by attracting macrophages and monocytes to further amplify inflammatory processes and contribute to disease progression. However, CCL7-specific pathological signaling pathways need to be further confirmed in these chronic diseases. Given the multiple redundancy system among chemokines and their receptors, further experimental and clinical studies are needed to clarify whether direct CCL7 inhibition mechanisms could be a promising therapeutic approach to attenuating the development of cardiovascular disease, diabetes mellitus, and kidney disease.

原文English
文章編號185
期刊Cardiovascular Diabetology
21
發行號1
DOIs
出版狀態Published - 12月 2022

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