Cancer as an infectious disease: A different treatment alternative using a combination of tigecycline and pyrvinium pamoate – An example of breast cancer

Shu Wei Huang, Ming Tsung Sun, Wen Sen Lee, Ying shih Su, Yi Tzu Lee, Ming Hsien Chiang, Yung Chih Wang, Ya Sung Yang, Shian Chiuan Tzeng, Tien Yuan Wu, Jui Sheng Sun, Feng Huei Lin*

*此作品的通信作者

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Background: Tigecycline is an antibiotic that well tolerated for treating complicated infections. It has received attention as an anti-cancer agent and expected to solve two major obstacles, sides effects that accompany chemotherapy and drug resistance, in the breast cancer treatment. However, previous studies reported that the levels in the blood are typically low of tigecycline, so higher doses are needed to treat cancer, that may increase the risk of side effects. To achieve better anti-cancer effects for tigecycline, we need to find a novel adjunct agent. Methods: In this study, we used different concentration of pyrvinium pamoate combined with tigecycline to treat cell. And assess the effect of two drugs in inhibit cell proliferation, induce cell autophagy, or increase cell apoptosis to evaluate the consequent of combined therapy. Results: We observed that after the combined therapy, the cell cycle arrest at G1/s phase, the level of p21 increased, but decreased the levels of CDK2. Others, two drugs via different mechanisms to inhibit cancer cell proliferation and with selective cytotoxic to different cell lines. That could enhance the effect of breast cancer treatment. Conclusion: Combining low dose of tigecycline use with pyrvinium pamoate is a novel approach for breast cancer treatment. Appropriate combined therapy in breast cancer is recommended to improve outcomes. Other problems like drug resistance occur in patients or the microbes surrounding breast tissues would confer susceptibility to cancers then influence the effectiveness of treatment, which could be improved through combined therapy.

原文English
頁(從 - 到)51-59
頁數9
期刊Journal of Microbiology, Immunology and Infection
55
發行號1
DOIs
出版狀態Published - 2月 2022

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