摘要
A radical-chain addition of allyl bromides to aryl alkenes, vinyl ester, and vinyl phthalimide was studied in which elusive β-bromoalkyl radicals were trapped efficiently to give 5-bromo-1-pentenes in good to high yields (16 examples). A subsequent carbonylative radical cyclization with AIBN/Bu3SnH/CO was successful in giving the corresponding 3,5-disubstituted cyclohexanone derivatives in moderate yields. Synthesis of a piperidine ring was also successful by subsequent reaction with primary amine.
原文 | English |
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頁(從 - 到) | 5198-5200 |
頁數 | 3 |
期刊 | Organic Letters |
卷 | 19 |
發行號 | 19 |
DOIs | |
出版狀態 | Published - 6 10月 2017 |