Boundary-condition dependent elasticity of short double-stranded DNA molecules

Yih Fan Chen*, K. Raghunathan, David Wilson, Jens Christian Meiners

*此作品的通信作者

研究成果: Conference contribution同行評審

摘要

We have measured the entropic elasticity of ds-DNA molecules ranging from 247 to 1298 base pairs in length, using axial optical force-clamp tweezers. We show that entropic end effects and excluded-volume forces become significant for such short molecules. In this geometry, the effective persistence length of the shortest molecules decreases by a factor of two compared to the established value for long molecules, and excluded-volume forces extend the molecules to about one third of their nominal contour lengths in the absence of any external forces. We interpret these results in the framework of a modified wormlike chain model.

原文English
主出版物標題Optical Trapping and Optical Micromanipulation VI
DOIs
出版狀態Published - 2009
事件Optical Trapping and Optical Micromanipulation VI - San Diego, CA, United States
持續時間: 2 8月 20096 8月 2009

出版系列

名字Proceedings of SPIE - The International Society for Optical Engineering
7400
ISSN(列印)0277-786X

Conference

ConferenceOptical Trapping and Optical Micromanipulation VI
國家/地區United States
城市San Diego, CA
期間2/08/096/08/09

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