BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase

Masaaki Hayashi, Richard I. Tapping, Ta Hsiang Chao, Jeng Fan Lo, Charles C. King, Young Yang, Jiing Dwan Lee*

*此作品的通信作者

研究成果: Article同行評審

109 引文 斯高帕斯(Scopus)

摘要

Activation of the mammalian mitogen-activated protein kinase known as BMK1 is required for growth factor-induced cell proliferation. To understand the mechanism by which BMK1 mediates this cellular response, this kinase was used as bait in a yeast two-hybrid-based library screening. Here, we report the identification of serum and glucocorticoid-inducible kinase (SGK) as a cellular protein that physically interacts with BMK1. During growth factor-induced cell stimulation, BMK1 activates SGK by phosphorylation at serine 78. This BMK1-mediated phosphorylation event is necessary for the activation of SGK and, more importantly, for cell proliferation induced by growth factors.

原文English
頁(從 - 到)8631-8634
頁數4
期刊Journal of Biological Chemistry
276
發行號12
DOIs
出版狀態Published - 23 3月 2001

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