Blood pressure variability and cognitive dysfunction: A systematic review and meta-analysis of longitudinal cohort studies

Tzu Jung Chiu, Jiunn Tyng Yeh, Chi Jung Huang, Chern En Chiang, Shih Hsien Sung, Chen Huan Chen, Hao Min Cheng*

*此作品的通信作者

研究成果: Review article同行評審

10 引文 斯高帕斯(Scopus)

摘要

The variability of blood pressure (BPV) has been suggested as a clinical indicator for cognitive dysfunction, yet the results from clinical studies are variable. This study investigated the relationship between BPV and the risk of cognitive decline or dementia. Bibliographic databases, including PubMed, Scopus, and Embase, were searched systematically for longitudinal cohort studies with BPV measurements and neuropsychological examinations or dementia diagnosis. A traditional meta-analysis with subgroup analysis, and a further dose-response meta-analysis were conducted. Twenty cohort studies with 7 924 168 persons were included in this review. The results showed that a higher systolic BPV (SBPV), when measured with the coefficient of variation (SBP-CV) or standard deviation (SBP-SD), was associated with a higher risk of all-cause dementia diagnosis but not incidence of cognitive decline on neuropsychological examinations. In subgroup analysis, the effect was more prominent when using BPV of shorter timeframes, during shorter follow-ups, or among the elderly aged more than 65 years. No dose-response relationship could be found. Our study suggested possible positive associations between SBPV and the risk of dementia. Further studies are required to validate these findings.

原文English
頁(從 - 到)1463-1482
頁數20
期刊Journal of Clinical Hypertension
23
發行號8
DOIs
出版狀態Published - 8月 2021

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