Biopsy diagnosis of oral carcinoma by the combination of morphological and spectral methods based on embedded relay lens microscopic hyperspectral imaging system

Yang-Mang Ou, Yao Fang Hsieh*, Cheng Chung Lee

*此作品的通信作者

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Cytopathological examination through biopsy is very important for carcinoma detection. The embedded relay lens microscopic hyperspectral imaging system (ERL-MHIS) provides a morphological image of a biopsy sample and the spectrum of each pixel in the image simultaneously. Based on the ERL-MHIS, this work develops morphological and spectral methods to diagnose oral carcinoma biopsy. In morphological discrimination, the fractal dimension method is applied to differentiate between normal and abnormal tissues. In spectral identification, normal and cancerous cells are distinguished using five methods. However, the spectra of normal and cancerous cells vary with patient. The diagnostic performances of the five methods are thus not ideal. Hence, the proposed cocktail approach is used to determine the effectiveness of the spectral methods in correlating with the sampling conditions. And then we use a combination of effective spectral methods according to the sample conditions for diagnosing a sample. A total of 68 biopsies from 34 patients are analyzed using the ERL-MHIS. The results demonstrate a sensitivity of 90 ± 4.53% and a specificity of 87.8 ± 5.21%. Furthermore, in our survey, this system is the first time utilized to study oral carcinoma biopsies.

原文English
頁(從 - 到)437-447
頁數11
期刊Journal of Medical and Biological Engineering
35
發行號4
DOIs
出版狀態Published - 1 1月 2015

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