Biomimetic Total Synthesis of the Spiroindimicin Family of Natural Products

Xikang Zheng, Yan Li, Mengtie Guan, Lingyue Wang, Shilong Wei, Yi Cheng Li, Chin Yuan Chang, Zhengren Xu*


研究成果: Article同行評審

3 引文 斯高帕斯(Scopus)


A unified strategy for the biomimetic total synthesis of the spiroindimicin family of natural products was reported. Key transformations include a one-pot two-enzyme-catalyzed oxidative dimerization of L-tryptophan/5-chloro-L-tryptophan to afford the bis-indole precursors chromopyrrolic acid/5′,5′′-dichloro-chromopyrrolic acid, and regioselective C3′−C2′′ and C3′−C4′′ bond formation converting a common bis-indole skeleton to two skeletally different natural products, including (±)-spiroindimicins D and G with a [5,5] spiro-ring skeleton, and (±)-spiroindimicins A and H with a [5,6] spiro-ring skeleton, respectively.

期刊Angewandte Chemie - International Edition
出版狀態Accepted/In press - 2022


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