Biomedical nanoparticle carriers with combined thermal and magnetic responses

Ting Yu Liu, Shang Hsiu Hu, Dean-Mo Liu, San-Yuan Chen, I. Wei Chen*


研究成果: Review article同行評審

258 引文 斯高帕斯(Scopus)


Several biocompatible polymers are capable of large responses to small temperature changes around 37 °C. In water, their responses include shrinkage and swelling as well as transitions in wettability. These properties have been harnessed for biomedical applications such as tissue engineering scaffolds and drug delivery carriers. A soft material/hard material hybrid in which a magnetic metal or oxide is embedded in a temperature-responsive polymer matrix can combine the thermal sensitivity with magnetic signatures. Importantly, nanosizing such construct brings about new desirable features of extremely fast thermal response time, small magnetic hysteresis and enhanced magnetic susceptibility. Remote magnetic maneuvering and heating of the hybrid nanocolloids makes possible such applications as high-throughput enzyme separation and cell screening. Robust drug release on demand may also be obtained using these colloids and nanoparticle-derived thin film devices of combined thermal magnetic sensitivity.

頁(從 - 到)52-65
期刊Nano Today
出版狀態Published - 1 2月 2009


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