TY - JOUR
T1 - Beneficial effects of noni (Morinda citrifolia L.) juice on livers of high-fat dietary hamsters
AU - Lin, Yi Ling
AU - Chang, Yuan Yen
AU - Yang, Deng Jye
AU - Tzang, Bor Show
AU - Chen, Yi Chen
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Polyphenols in noni juice (NJ) are mainly composed of phenolic acids, mainly gentisic, p-hydroxybenoic, and chlorogenic acids. To investigate the beneficial effects of NJ on the liver, hamsters were fed with two diets, normal-fat and high-fat diets. Furthermore, high-fat dietary hamsters were received distilled water, and 3, 6, and 9 mL NJ/kg BW, respectively. After a 6-week feeding period, the increased (p < 0.05) sizes of liver and visceral fat in high-fat dietary hamsters compared to the control hamsters were ameliorated (p < 0.05) by NJ supplementation. NJ also decreased (p < 0.05) serum/liver lipids but enhanced (p < 0.05) daily faecal lipid/bile acid outputs in the high-fat dietary hamsters. High-fat dietary hamsters supplemented with NJ had higher (p < 0.05) liver antioxidant capacities but lowered (p < 0.05) liver iNOS, COX-2, TNF-α, and IL-1β expressions, gelatinolytic levels of MMP9, and serum ALT values compared to those without NJ. Hence, NJ protects liver against a high-fat dietary habit via regulations of antioxidative and anti-inflammatory responses.
AB - Polyphenols in noni juice (NJ) are mainly composed of phenolic acids, mainly gentisic, p-hydroxybenoic, and chlorogenic acids. To investigate the beneficial effects of NJ on the liver, hamsters were fed with two diets, normal-fat and high-fat diets. Furthermore, high-fat dietary hamsters were received distilled water, and 3, 6, and 9 mL NJ/kg BW, respectively. After a 6-week feeding period, the increased (p < 0.05) sizes of liver and visceral fat in high-fat dietary hamsters compared to the control hamsters were ameliorated (p < 0.05) by NJ supplementation. NJ also decreased (p < 0.05) serum/liver lipids but enhanced (p < 0.05) daily faecal lipid/bile acid outputs in the high-fat dietary hamsters. High-fat dietary hamsters supplemented with NJ had higher (p < 0.05) liver antioxidant capacities but lowered (p < 0.05) liver iNOS, COX-2, TNF-α, and IL-1β expressions, gelatinolytic levels of MMP9, and serum ALT values compared to those without NJ. Hence, NJ protects liver against a high-fat dietary habit via regulations of antioxidative and anti-inflammatory responses.
KW - Anti-inflammatory response
KW - Antioxidant capacity
KW - Nonalcoholic fatty liver
KW - Noni juice
KW - Polyphenol
UR - http://www.scopus.com/inward/record.url?scp=84874944662&partnerID=8YFLogxK
U2 - 10.1016/j.foodchem.2013.02.035
DO - 10.1016/j.foodchem.2013.02.035
M3 - Article
C2 - 23578611
AN - SCOPUS:84874944662
SN - 0308-8146
VL - 140
SP - 31
EP - 38
JO - Food Chemistry
JF - Food Chemistry
IS - 1-2
ER -