Baculovirus as a gene delivery vector: Recent understandings of molecular alterations in transduced cells and latest applications

Chi Yuan Chen, Chin Yu Lin, Guan-Yu Chen, Yu Chen Hu*

*此作品的通信作者

研究成果: Review article同行評審

113 引文 斯高帕斯(Scopus)

摘要

Baculovirus infects insects in nature and is non-pathogenic to humans, but can transduce a broad range of mammalian and avian cells. Thanks to the biosafety, large cloning capacity, low cytotoxicity and non-replication nature in the transduced cells as well as the ease of manipulation and production, baculovirus has gained explosive popularity as a gene delivery vector for a wide variety of applications. This article extensively reviews the recent understandings of the molecular mechanisms pertinent to baculovirus entry and cellular responses, and covers the latest advances in the vector improvements and applications, with special emphasis on antiviral therapy, cancer therapy, regenerative medicine and vaccine.

原文English
頁(從 - 到)618-631
頁數14
期刊Biotechnology Advances
29
發行號6
DOIs
出版狀態Published - 11月 2011

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