Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

Angelika Gutenberg; Melissa Landek-Salgado; Shey-Cherng Tzou; Isabella Lupi; Abby Geis; Hiroaki Kimura; Patrizio Caturegli

doi:10.1586/eem.09.37

Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

Angelika Gutenberg, Melissa Landek-Salgado, Shey-Cherng Tzou, Isabella Lupi, Abby Geis, Hiroaki Kimura, Patrizio Caturegli^*

^*此作品的通信作者

分子醫學與生物工程研究所

研究成果: Review article › 同行評審

15 引文斯高帕斯（Scopus）

摘要

Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.

原文	English
頁（從 - 到）	681-698
頁數	18
期刊	Expert Review of Endocrinology and Metabolism
卷	4
發行號	6
DOIs	https://doi.org/10.1586/eem.09.37
出版狀態	Published - 11月 2009

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abstract = "Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.",

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AU - Tzou, Shey-Cherng

AU - Lupi, Isabella

AU - Geis, Abby

AU - Kimura, Hiroaki

AU - Caturegli, Patrizio

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AB - Autoimmune hypophysitis is an increasingly recognized disorder that enters in the differential diagnosis of nonfunctioning pituitary masses. The differential diagnosis of these conditions is challenging because of similar clinical presentations and radiological signs. This review describes the essential features of hypophysitis and the other nonfunctioning pituitary masses. It also emphasizes a recently described feature of hypophysitis: its appearance with unexpectedly high frequency in patients receiving treatments that abrogate the function of cytotoxic T lymphocyte antigen 4.

KW - Autoimmunity

KW - CTLA-4 blockade

KW - Hypophysitis

KW - MRI

KW - Monoclonal antibodies

KW - Nonfunctioning sellar masses

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Autoimmune hypophysitis: Expanding the differential diagnosis to CTLA-4 blockade

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