Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

Ya Shih Tseng; Ching Cherng Tzeng; Chi Ying F. Huang; Ping Hong Chen; Allen Wen Hsiang Chiu; Pei Yin Hsu; Guan Cheng Huang; Yu Chun Wang; Hsiao Sheng Liu

doi:10.1016/j.canlet.2005.10.014

Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

Ya Shih Tseng, Ching Cherng Tzeng, Chi Ying F. Huang, Ping Hong Chen, Allen Wen Hsiang Chiu, Pei Yin Hsu, Guan Cheng Huang, Yu Chun Wang, Hsiao Sheng Liu^*

^*此作品的通信作者

研究成果: Article › 同行評審

14 引文斯高帕斯（Scopus）

摘要

Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

原文	English
頁（從 - 到）	93-101
頁數	9
期刊	Cancer Letters
卷	241
發行號	1
DOIs	https://doi.org/10.1016/j.canlet.2005.10.014
出版狀態	Published - 8 9月 2006

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@article{3af1c723ebfd485291cfa4504b346026,

title = "Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer",

abstract = "Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.",

keywords = "Arsenic, Aurora-A, Blackfoot-endemic-area, Ha-ras mutation",

author = "Tseng, {Ya Shih} and Tzeng, {Ching Cherng} and Huang, {Chi Ying F.} and Chen, {Ping Hong} and Chiu, {Allen Wen Hsiang} and Hsu, {Pei Yin} and Huang, {Guan Cheng} and Wang, {Yu Chun} and Liu, {Hsiao Sheng}",

note = "Funding Information: This work was supported by grant CMFHR9316 from the Chi-Mei Medical Center and grant NSC93-2321-B006-009 from the National Science Council, Taiwan, ROC. ",

year = "2006",

month = sep,

day = "8",

doi = "10.1016/j.canlet.2005.10.014",

language = "English",

volume = "241",

pages = "93--101",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

TY - JOUR

T1 - Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

AU - Tseng, Ya Shih

AU - Tzeng, Ching Cherng

AU - Huang, Chi Ying F.

AU - Chen, Ping Hong

AU - Chiu, Allen Wen Hsiang

AU - Hsu, Pei Yin

AU - Huang, Guan Cheng

AU - Wang, Yu Chun

AU - Liu, Hsiao Sheng

N1 - Funding Information: This work was supported by grant CMFHR9316 from the Chi-Mei Medical Center and grant NSC93-2321-B006-009 from the National Science Council, Taiwan, ROC.

PY - 2006/9/8

Y1 - 2006/9/8

N2 - Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

AB - Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-. ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-. ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

KW - Arsenic

KW - Aurora-A

KW - Blackfoot-endemic-area

KW - Ha-ras mutation

UR - http://www.scopus.com/inward/record.url?scp=39049177016&partnerID=8YFLogxK

U2 - 10.1016/j.canlet.2005.10.014

DO - 10.1016/j.canlet.2005.10.014

M3 - Article

C2 - 16338065

AN - SCOPUS:39049177016

SN - 0304-3835

VL - 241

SP - 93

EP - 101

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

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