TY - JOUR
T1 - Associations of serum uric acid levels with arterial wave reflections and central systolic blood pressure
AU - Hsu, Pai Feng
AU - Chuang, Shao Yuan
AU - Cheng, Hao Min
AU - Sung, Shih Hsien
AU - Ting, Chih Tai
AU - Lakatta, Edward G.
AU - Yin, Frank C.P.
AU - Chou, Pesus
AU - Chen, Chen Huan
N1 - Funding Information:
This work was supported by a grant from the National Science Council (NSC 99-2314-B-010-034-MY3 ) and intramural grants ( V97C1-101 , V98C1-028 , and V99C1-091 ) from Taipei Veterans General Hospital, Taiwan, Republic of China , and was supported in part by the Intramural Research Program of the NIH, National Institute on Aging .
PY - 2013/10/3
Y1 - 2013/10/3
N2 - Background Uric acid may be involved in the pathogenesis of hypertension. We investigated the roles of four major hemodynamic parameters of blood pressure, including arterial stiffness, wave reflections, cardiac output (CO), and total peripheral resistance (TPR), in the association between uric acid and central systolic blood pressure (SBP-c). Methods A sample of 1303 normotensive and untreated hypertensive Taiwanese participants (595 women, aged 30-79 years) was drawn from a community-based survey. Study subjects' baseline characteristics, biochemical parameters, carotid-femoral pulse wave velocity (cf-PWV), amplitude of the backward pressure wave decomposed from a calibrated tonometry-derived carotid pressure waveform (Pb), CO, TPR, and SBP-c were analyzed. Results In multi-variate analyses adjusted for age, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate, uric acid significantly correlated with Pb and cf-PWV in men, and Pb and TPR in women. The correlation between uric acid and Pb remained significant in men and women when cf-PWV was further adjusted. In the final multi-variate prediction model (model r2 = 0.839) for SBP-c, the significant independent variables included uric acid (partial r2 = 0.005), Pb (partial r2 = 0.651), cf-PWV (partial r2 = 0.005), CO (partial r2 = 0.062), TPR (partial r2 = 0.021), with adjustment for age, sex, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate. Conclusions Uric acid was significantly independently associated with wave reflections, which is the dominant determinant of SBP-c. Uric acid was also significantly associated with SBP-c independently of the major hemodynamic parameters.
AB - Background Uric acid may be involved in the pathogenesis of hypertension. We investigated the roles of four major hemodynamic parameters of blood pressure, including arterial stiffness, wave reflections, cardiac output (CO), and total peripheral resistance (TPR), in the association between uric acid and central systolic blood pressure (SBP-c). Methods A sample of 1303 normotensive and untreated hypertensive Taiwanese participants (595 women, aged 30-79 years) was drawn from a community-based survey. Study subjects' baseline characteristics, biochemical parameters, carotid-femoral pulse wave velocity (cf-PWV), amplitude of the backward pressure wave decomposed from a calibrated tonometry-derived carotid pressure waveform (Pb), CO, TPR, and SBP-c were analyzed. Results In multi-variate analyses adjusted for age, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate, uric acid significantly correlated with Pb and cf-PWV in men, and Pb and TPR in women. The correlation between uric acid and Pb remained significant in men and women when cf-PWV was further adjusted. In the final multi-variate prediction model (model r2 = 0.839) for SBP-c, the significant independent variables included uric acid (partial r2 = 0.005), Pb (partial r2 = 0.651), cf-PWV (partial r2 = 0.005), CO (partial r2 = 0.062), TPR (partial r2 = 0.021), with adjustment for age, sex, waist circumference, body mass index, creatinine, total cholesterol, smoking, and heart rate. Conclusions Uric acid was significantly independently associated with wave reflections, which is the dominant determinant of SBP-c. Uric acid was also significantly associated with SBP-c independently of the major hemodynamic parameters.
KW - Arterial stiffness
KW - Hypertension
KW - Uric acid
KW - Wave reflection
KW - c-Peptide
UR - http://www.scopus.com/inward/record.url?scp=84885632063&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2013.01.164
DO - 10.1016/j.ijcard.2013.01.164
M3 - Article
C2 - 23453449
AN - SCOPUS:84885632063
SN - 0167-5273
VL - 168
SP - 2057
EP - 2063
JO - International Journal of Cardiology
JF - International Journal of Cardiology
IS - 3
ER -