Association of nonsynonymous substitutions in the intermediate region of the vacA gene of helicobacter pylori with gastric diseases in Taiwan

Shew Meei Sheu; Kuei Hsiang Hung; Bor Shyang Sheu; Hsiao Bai Yang; Jiunn Jong Wu

doi:10.1128/JCM.01651-08

Association of nonsynonymous substitutions in the intermediate region of the vacA gene of helicobacter pylori with gastric diseases in Taiwan

Shew Meei Sheu
, Kuei Hsiang Hung
, Bor Shyang Sheu
, Hsiao Bai Yang
, Jiunn Jong Wu^*

^*此作品的通信作者

醫學生物技術暨檢驗學系

研究成果: Article › 同行評審

12 引文斯高帕斯（Scopus）

摘要

The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGIT SSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the il-type cluster C sequence could be a marker of VacA in the Taiwanese strains.

原文	English
頁（從 - 到）	249-251
頁數	3
期刊	Journal of Clinical Microbiology
卷	47
發行號	1
DOIs	https://doi.org/10.1128/JCM.01651-08
出版狀態	Published - 1月 2009

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10.1128/JCM.01651-08

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abstract = "The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGIT SSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the il-type cluster C sequence could be a marker of VacA in the Taiwanese strains.",

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AU - Sheu, Shew Meei

AU - Hung, Kuei Hsiang

AU - Sheu, Bor Shyang

AU - Yang, Hsiao Bai

AU - Wu, Jiunn Jong

PY - 2009/1

Y1 - 2009/1

N2 - The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGIT SSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the il-type cluster C sequence could be a marker of VacA in the Taiwanese strains.

AB - The amino acid sequences corresponding to the vacA intermediate region from 39 isolates of Helicobacter pylori were investigated. The substitution of a G for the third S in the i1-type cluster B sequence (QASEGIT SSK) conferred a greater risk of gastric diseases (P < 0.03; Fisher's exact test). The conserved substitutions of an F for the Y in the cluster A sequence and of an M for the second N in the il-type cluster C sequence could be a marker of VacA in the Taiwanese strains.

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JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 1

ER -

Association of nonsynonymous substitutions in the intermediate region of the vacA gene of helicobacter pylori with gastric diseases in Taiwan

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