Assessment of the value of carcinoembryonic antigen reduction ratio as a prognosis factor in rectal cancer

Chih Sheng Huang, Jen Kou Lin, Ling Wei Wang, Wen Yih Liang, Chun Chi Lin, Yuan Tzu Lan, Huann Sheng Wang, Shung Haur Yang, Jeng Kai Jiang, Wei Shone Chen, Tzu Chen Lin, Shih Ching Chang*

*此作品的通信作者

研究成果: Article同行評審

11 引文 斯高帕斯(Scopus)

摘要

Background Carcinoembryonic antigen (CEA) is the most widely used tumor marker for colorectal cancer. This study aimed to investigate the role of CEA reduction ratio after preoperative chemoradiotherapy (CRT). Methods We enrolled 284 patients who underwent preoperative CRT followed by radical surgical resection. Patients were divided into 3 groups: serum CEA levels before CRT (pre-CRT CEA) less than 5 ng/mL (group 1); pre-CRT CEA of 5 ng/mL or more with CEA reduction ratio of 50% or more (group 2); and pre-CRT CEA of 5 ng/mL or more with CEA reduction ratio less than 50% (group 3). Results The 5-year disease-free survival (DFS) rate was not different between groups 1 (71.8%) and 2 (69.4%) but was significantly lower in group 3 (49.5%). CEA group, lymph node status after CRT (ypN) stage, and histologic type were independent prognostic factors for DFS on multivariate analysis. Conclusions CEA reduction ratio might be an independent prognostic factor for DFS in rectal cancer patients treated with preoperative CRT and radical surgery.

原文English
頁(從 - 到)99-105
頁數7
期刊American Journal of Surgery
208
發行號1
DOIs
出版狀態Published - 7月 2014

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