Assembly of viral membrane proteins

J. Krüger, W. B. Fischer*

*此作品的通信作者

研究成果: Article同行評審

40 引文 斯高帕斯(Scopus)

摘要

The generation of computational models is an alternative route to obtain reliable structures for the oligomeric state of membrane proteins. A strategy has been developed to search the conformational space of all possible assemblies in a reasonable time, taking symmetry considerations into account. The methodology tested on M2 from influenza A, shows an excellent agreement with established structures. For Vpu from HIV-1 a series of conformational distinct structures are proposed. For the first time a structural model for a fully assembled transmembrane part of 3a from SARS-CoV is proposed.

原文English
頁(從 - 到)2503-2513
頁數11
期刊Journal of Chemical Theory and Computation
5
發行號9
DOIs
出版狀態Published - 9月 2009

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