Application of TEOS/PDMS ORMOSIL in the fabriction of amperometric biosensor

Chiun-Jye Yuan*, Wei Jen Ho

*此作品的通信作者

研究成果: Conference contribution同行評審

2 引文 斯高帕斯(Scopus)

摘要

Silica xerogel was widely used in the development of biosensors by coupling the desired biological components to various transducers. Unfortunately, the application of xerogels is limited due to their poor drying behavior and poor mechanical properties. ORMOSILs, organically modified ceramic materials, are synthesized using sol-gel techniques and permit the fabrication of a wide variety of compositions as thick coatings or monoliths. In this study the availability of poly(dimethylsiloxane) (PDMS)-modified ORMOSIL in the immobilization of enzymes as well as its application in the fabrication of amperometric biosensor was investigated. We demonstrated that the stability of encapsulated horseradish peroxidase can be greatly enhanced in TEOS/PDMS ORMOSIL compared with TEOS xerogel. The synthesized monoliths exhibited high transparency and crack-free. The enzyme electrode based on glucose oxidase encapsulated ORMOSIL on Pd electrode was fabricated and characterized electrochemically. The results indicate that TEOS/PDMS ORMOSIL has a great potential for the immobilization of biological molecules as well as the fabrication of biosensors.

原文English
主出版物標題2004 IEEE International Workshop on Biomedical Circuits and Systems
DOIs
出版狀態Published - 1 十二月 2004
事件2004 IEEE International Workshop on Biomedical Circuits and Systems - Singapore, Singapore
持續時間: 1 十二月 20043 十二月 2004

出版系列

名字2004 IEEE International Workshop on Biomedical Circuits and Systems

Conference

Conference2004 IEEE International Workshop on Biomedical Circuits and Systems
國家/地區Singapore
城市Singapore
期間1/12/043/12/04

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