Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin

Guewha Steven Huang; Yu-Shiun Chen; Xin-Yau Lin

doi:10.1109/NANO.2007.4601129

Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin

Guewha Steven Huang^*, Yu-Shiun Chen, Xin-Yau Lin

^*此作品的通信作者

生物科技學系

研究成果: Chapter › 同行評審

1 引文斯高帕斯（Scopus）

摘要

We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.

原文	English
主出版物標題	2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3
發行者	IEEE
頁面	7-10
ISBN（列印）	978-1-4244-0607-4
DOIs	https://doi.org/10.1109/NANO.2007.4601129
出版狀態	Published - 2007
事件	2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007 - Hong Kong, China 持續時間: 2 8月 2007 → 5 8月 2007

Conference

Conference	2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007
國家/地區	China
城市	Hong Kong
期間	2/08/07 → 5/08/07

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10.1109/NANO.2007.4601129

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title = "Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin",

abstract = "We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.",

keywords = "Immunoglobulin; Quartz Crystal Microbalance; Matrix; Biosensor; Flexibility",

author = "Huang, {Guewha Steven} and Yu-Shiun Chen and Xin-Yau Lin",

year = "2007",

doi = "10.1109/NANO.2007.4601129",

language = "English",

isbn = "978-1-4244-0607-4",

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Huang, GS, Chen, Y-S & Lin, X-Y 2007, Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin. 於 2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3. IEEE, 頁 7-10, 2007 7th IEEE International Conference on Nanotechnology - IEEE-NANO 2007, Hong Kong, China, 2/08/07. https://doi.org/10.1109/NANO.2007.4601129

TY - CHAP

T1 - Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin

AU - Huang, Guewha Steven

AU - Chen, Yu-Shiun

AU - Lin, Xin-Yau

PY - 2007

Y1 - 2007

N2 - We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.

AB - We have constructed a piezoelectric sensor matrix with the capability of measuring the flexibility of immunoglobulin. The matrix consisted of 6 independent quartz crystal microbalance (QCM) coated with gold nanoparticles (GNP) of 3.5, 5, 12, 17, and 37 nm, and BSA. The detection was performed simultaneously. Antiserum against GNP bound to QCMs coated with 3.5 nm GNP and maximized for 5 nm GNP-coated QCM. To our best knowledge, this is the first biosensor sensing the topological change and flexibility of biological macromolecule.

KW - Immunoglobulin; Quartz Crystal Microbalance; Matrix; Biosensor; Flexibility

U2 - 10.1109/NANO.2007.4601129

DO - 10.1109/NANO.2007.4601129

M3 - Chapter

SN - 978-1-4244-0607-4

SP - 7

EP - 10

BT - 2007 7TH IEEE CONFERENCE ON NANOTECHNOLOGY, VOL 1-3

PB - IEEE

Y2 - 2 August 2007 through 5 August 2007

ER -

Application of Nanobiotechnology to Construct a Piezoelectric Sensor Matrix Sensing the Flexibility of Immunoglobulin

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