Appetite hormone dysregulation, body mass index, and emotional dysregulation in nonobese adolescents with first-episode schizophrenia, bipolar disorder, and major depressive disorder: a cross-sectional association study

Ju Wei Hsu, Li Chi Chen, Ya Mei Bai, Kai Lin Huang, Shih Jen Tsai, Tung Ping Su, Mu Hong Chen*

*此作品的通信作者

研究成果: Article同行評審

1 引文 斯高帕斯(Scopus)

摘要

Background Evidence has suggested that emotional dysregulation is a transdiagnostic feature in schizophrenia and major affective disorders. However, the relationship between emotional dysregulation and appetite hormone disturbance remains unknown in nonobese adolescents with first-episode schizophrenia, bipolar disorder, and major depressive disorder. Methods In total, 22 adolescents with schizophrenia; 31 with bipolar disorder; 33 with major depressive disorder; and 41 healthy age-, sex-, and body mass index (BMI)/BMI percentile-matched controls were enrolled for assessing levels of appetite hormones, namely leptin, ghrelin, insulin, and adiponectin. Emotional regulation symptoms were measured using the parent-reported Child Behavior Checklist Dysregulation Profile. Results Adolescents with first-episode schizophrenia, bipolar disorder, and major depressive disorder exhibited greater emotional dysregulation symptoms than the control group (P =.037). Adolescents with bipolar disorder demonstrated higher log-transformed levels of insulin (P =.029) and lower log-transformed levels of leptin (P =.018) compared with the control group. BMI (P <.05) and log-transformed ghrelin levels (P =.028) were positively correlated with emotional dysregulation symptoms. Discussion Emotional dysregulation and appetite hormone disturbance may occur in the early stage of severe mental disorders. Further studies are required to clarify the unidirectional or bidirectional association of emotional dysregulation with BMI/BMI percentile and appetite hormones among patients with severe mental disorder.

原文English
頁(從 - 到)629-636
頁數8
期刊CNS Spectrums
28
發行號5
DOIs
出版狀態Published - 10 10月 2023

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