TY - JOUR
T1 - Antioxidant and Anti-Inflammatory Constituents from Rhamnus crenata
AU - Chin, Chih Hui
AU - Liaw, Chia Ching
AU - Chang, Tsung Hsien
AU - Shu, Chih Wen
AU - Sung, Ping Jyun
AU - Cheng, Ming Jen
AU - Wang, I. Chou
AU - Chen, Jih Jung
N1 - Publisher Copyright:
© Springer Science+Business Media, LLC, part of Springer Nature 2024.
PY - 2024/1
Y1 - 2024/1
N2 - A new naphthalene derivative, 7-acetyl-8-hydroxy-3-methoxy-6-methylnaphthalen-1-yl acetate (1), has been isolated from the stem of Rhamnus crenata, together with eight known compounds 2–9. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, emodin (3), physcion (4), quercetin 3-O-α-L-rhamnopyranoside (5), and quercetin 7-O-α-L-rhamnopyranoside (6) showed potent inhibition with IC50 values of 33.18 ± 2.73, 35.52 ± 3.27, 28.05 ± 1.85, and 26.41 ± 3.01 μM, respectively, against LPS-induced NO generation. In addition, compounds 3, 5, and 6 also showed potent DPPH radical scavenging activities with IC50 values of 95.47 ± 6.18, 68.27 ± 5.38, and 66.25 ± 4.20 μM, respectively.
AB - A new naphthalene derivative, 7-acetyl-8-hydroxy-3-methoxy-6-methylnaphthalen-1-yl acetate (1), has been isolated from the stem of Rhamnus crenata, together with eight known compounds 2–9. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, emodin (3), physcion (4), quercetin 3-O-α-L-rhamnopyranoside (5), and quercetin 7-O-α-L-rhamnopyranoside (6) showed potent inhibition with IC50 values of 33.18 ± 2.73, 35.52 ± 3.27, 28.05 ± 1.85, and 26.41 ± 3.01 μM, respectively, against LPS-induced NO generation. In addition, compounds 3, 5, and 6 also showed potent DPPH radical scavenging activities with IC50 values of 95.47 ± 6.18, 68.27 ± 5.38, and 66.25 ± 4.20 μM, respectively.
KW - Rhamnaceae
KW - Rhamnus crenata
KW - anti-inflammatory activity
KW - antioxidant
KW - naphthalene derivative
UR - http://www.scopus.com/inward/record.url?scp=85183623693&partnerID=8YFLogxK
U2 - 10.1007/s10600-024-04251-4
DO - 10.1007/s10600-024-04251-4
M3 - Article
AN - SCOPUS:85183623693
SN - 0009-3130
VL - 60
SP - 50
EP - 54
JO - Chemistry of Natural Compounds
JF - Chemistry of Natural Compounds
IS - 1
ER -