Antioxidant and Anti-Inflammatory Constituents from Rhamnus crenata

Chih Hui Chin, Chia Ching Liaw, Tsung Hsien Chang, Chih Wen Shu, Ping Jyun Sung, Ming Jen Cheng, I. Chou Wang, Jih Jung Chen*

*此作品的通信作者

研究成果: Article同行評審

摘要

A new naphthalene derivative, 7-acetyl-8-hydroxy-3-methoxy-6-methylnaphthalen-1-yl acetate (1), has been isolated from the stem of Rhamnus crenata, together with eight known compounds 2–9. The structure of new compound 1 was determined through spectroscopic and MS analyses. Among the isolates, emodin (3), physcion (4), quercetin 3-O-α-L-rhamnopyranoside (5), and quercetin 7-O-α-L-rhamnopyranoside (6) showed potent inhibition with IC50 values of 33.18 ± 2.73, 35.52 ± 3.27, 28.05 ± 1.85, and 26.41 ± 3.01 μM, respectively, against LPS-induced NO generation. In addition, compounds 3, 5, and 6 also showed potent DPPH radical scavenging activities with IC50 values of 95.47 ± 6.18, 68.27 ± 5.38, and 66.25 ± 4.20 μM, respectively.

原文English
頁(從 - 到)50-54
頁數5
期刊Chemistry of Natural Compounds
60
發行號1
DOIs
出版狀態Published - 1月 2024

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